Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Chemistry II

Karolinska Institutet invites applications for a Postdoc in the functional metabolomics of immuno-metabolism.

Area of responsibilities/description of the work
This position will focus on the role of small molecule metabolites in determining macrophage phenotype in relation to immuno-metabolic processes driving chronic low-grade inflammation. Low-grade, sustained, inflammation has been implicated in chronic diseases such as rheumatoid arthritis, multiple sclerosis, asthma and in particular cardiovascular disease (CVD). A variety of factors and mechanisms have been suggested to drive this type of inflammation, including genetic predisposition, the environment, the diet and the gut microbiome. With respect to CVD, epidemiological studies have indicated links to the metabolic syndrome, a collection of signs and symptoms centered on obesity, hypertension, and reduced insulin sensitivity. Emerging evidence suggests that metabolic factors (e.g., glucose, palmitate and insulin) that are dysregulated in metabolic disorders are important determinants of adipose tissue macrophage phenotype. Accordingly, to complement and better understand the functional characteristics identified in genomics studies, this collaborative project will perform molecular phenotyping studies to investigate the complexities of the immuno-metabolic interface. Duties will also include method development to further optimize our LC-HRMS-based metabolomics platform and adapt existing protocols to new biological matrices. This project involves a close collaboration with multiple groups at the University of Copenhagen, Karolinska Institute and University of Oxford to understand the role of small molecule metabolites in immuno-metabolism. There will accordingly be multiple opportunities to visit collaborators for extended research interactions.

The successful applicant will belong to the Integrative Molecular Phenotyping laboratory (http://metabolomics.se) in the Department of Medical Biochemistry and Biophysics. The Department has a strong and internationally recognized research tradition in the physiology and pathobiology of bioactive lipids, including awarding of the Noble Prize for the discovery of eicosanoids. The research environment includes working with state-of-the-art equipment, including multiple mass spectrometers. This 4-year project is a collaborative effort between the University of Copenhagen, Karolinska Institute and University of Oxford funded by the Novo Nordisk Foundation (NNF). This full-time position is temporary (two years), with potential for renewal for at least 2 more years.

We are looking for highly motivated candidates with a Ph.D. in mass spectrometry or bioanalytical chemistry and experience in small molecule mass spectrometry as well as biological sample preparation techniques. Candidates should have demonstrated experience in LC-MS based metabolomics. We are especially interested in candidates with prior experience working with large clinical studies. In addition, the applicant must have significant and demonstrable experience in dealing with data acquisition, analysis protocols and associated software. Experience with computer programming (e.g., R, Matlab) and multivariate statistics (e.g., SIMCA) would be highly advantageous. Excellent communication skills and an ability to interact socially and scientifically with other post docs and students in the laboratory and with collaborators are essential. Previous post doc experience and a strong publication record are strong merits.

Entry requirements
A person is eligible for a position as Postdoctoral Researcher if she or he has obtained a PhD or a foreign qualification deemed equivalent to a doctorate, no more than seven years before the last date of employment as postdoc. Applicants who have completed their degree no more than three years before the last date for applications will be given priority. Candidates who have completed their degree earlier than this date will receive equal priority if special grounds exist (e.g., parental leave, military service). Application Applications consisting of cover letter, full CV and references should be submitted via MyNetwork recruitment system.

Applications will be evaluated as received, with a preferred start date as soon as possible. The last date of application is January 31st, 2017.

Type of employment Temporary position longer than 6 months
Contract type Full time
Number of positions 1
Working hours 100 %
City Stockholm/Solna
County Stockholms län
Country Sweden
Reference number 2-4538/2016
  • Craig Wheelock, +46 (0)8-524 876 30
Union representative
  • Anne Edgren, OFR/S, P, O, +46 (0)8-616 16 29
  • Biborka Bereczky Veress, SACO, +46 (0)70-173 85 75
  • Henry Wölling, SEKO, +46 (0)8-524 840 80
Published 23.Nov.2016
Last application date 31.Jan.2017 11:59 PM CET

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