Karolinska Institutet, Department of Oncology-Pathology, Forskargrupp Mellstedt

At the Department of Oncology-Pathology basic, translational and clinical research and educational activities related to cancer is carried out. Approximately 300 people from over 40 nations are currently working at the department. 37 research groups with various cancer research profiles are involved and we have around 120 PhD students. The Department of Oncology-Pathology is responsible for undergraduate courses in Pathology, Oncology and Forensic Medicine for medical students, as well as for Tumor biology courses for biomedicine students and Pathology courses for opticians.

A doctoral position implies that a doctoral education project is available to which a PhD student is to be recruited. After the recruitment, an admission process to the doctoral education takes place. The decision on admission will not be taken until an individual study plan has been approved by the departmental admission board.

For more information regarding doctoral (PhD) education at Karolinska Institutet, see: http://www.ki.se/doctoral

Post-graduate education environment and research group
The Department of Oncology-Pathology announces a PhD student position within Håkan Mellstedt´s and Anders Österborg`s research group. The research group has a long-term experience of basic, translational and clinical research with focus on immune biology and immunotherapy of cancer, in particular of lymphoid malignancies. The research work aims at developing new targeted therapies for the treatment of these cancer forms, by the identification of tumor-specific molecular and immunological targets.

The PhD student will work within a well-established local research environment including both basic and clinical researchers. The group works in collaboration with other basic and clinical researchers within the Institution, at Karolinska Institutet and other universities, and within a network including many other research groups abroad.

The doctoral education project and the duties of the student
The doctoral education project is of translational kind, strictly based on the principles of bench-to bedside medicine and performed partly in collaboration with the clinical trial unit of the Hematology clinic and the Pathology Dpt. The project focuses on the characterization of the immune functions in patients with lymphoid malignancies, in particular chronic lymphocytic leukemia and Hodgkin´s lymphoma, and aims at investigating how immune functions are affected by the tumor and by different anti-cancer treatments. The research is meant to contribute to a deeper understanding of the immune biology of these diseases, which could contribute to improved clinical benefit and better toxicity profile of anti-cancer treatments.

The project plan includes immune monitoring of patients with lymphoid malignancies treated with chemotherapy, targeted therapy or combinations of these, within standard care practice or clinical trials as well as analysis of possible correlations between clinical parameters and laboratory and pathology findings. The ultimate goal is to find biological markers with potential clinical relevance.

Entry requirements for doctoral education at KI
To be eligible for doctoral education following requirements has to be met:

General entry requirements
A person meets the general entry requirements for doctoral/third-cycle/PhD education (according to Higher Education Ordinance Chapt 7, section 39) if he/she:

  1. has been awarded advanced/second-cycle/master qualification (i.e. master degree) or
  2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle/master level, or
  3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad.

Specific entry requirements
Proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school:
Proficiency in the English language can be documented by an internationally recognized test such as TOEFL or IELTS, see web-link below for more information.
Applicants who meet the general entry requirements (1 or 2 above) from a university in one of the Nordic countries fulfill the requirements in English.

For more information regarding general and specific entry requirements: http://ki.se/en/education/entry-requirements-eligibility-for-doctoral-education

Skills and personal qualities
We are seeking a highly-motivated student who has a strong interest in translational cancer research and tumor immunology. The project comprises both experimental analyses on tumor material and immune cells as well as analysis of clinical data incl. statistical processing. The applicant should preferably have a medical background and have some previous experience of translational clinical research. An MD degree as well as previous publications in the research field of the PhD project are highly meritorious.

Candidates should have between 6-12 months’ experience of practical laboratory work. In particular, previous experience of handling of patients’ primary material (e.g. fresh blood and tumor samples), flow cytometry, aseptic cell culture, immunohistochemistry, are of advantage. The applicant should be able to work independently in the lab as well as to interact effectively and work productively in a team of researchers with both clinical and basic research background, and with external collaborators. Good communication skills, both oral and written, are required, in English and preferably also in Swedish. Good skills in scientific writing in English are required.

Assessment criteria
A selection will be made among qualified applicants on the basis of the ability to benefit from doctoral education. Karolinska Institutet uses the following bases of assessment:
- Documented subject knowledge of relevance to the area of research
- Analytical skill
- Other documented knowledge or experience that may be relevant to doctoral studies in the subject

The qualifications of the applicants will be evaluated on an overall basis.

Terms and conditions
All doctoral students at KI receive financial support during their doctoral education and employment on a doctoral studentship is the most common sort of support. During the time between recruitment and admission a short-term employment can be offered for up to 6 months. Dr Marzia Palma is the main supervisor for the doctoral project. Professor Anders Österborg and Associate Prof. Lotta Hansson at the Department of Oncology-Pathology and Associate Prof Robert Månsson at the Department of Laboratory Medicine will be co-supervisors.

Application process
An application must contain the following documents in Swedish or English:

  • A personal letter and curriculum vitae
  • A copy of degree certificates and associated certificates
  • A copy of degree projects and any previous publications

The application is to be submitted through the MyNetwork recruitment system.

Type of employment DOCTOR_POSITION
Contract type Full time
Reference number 2-4029/2017
  • Marzia Palma, PhD, marzia.palma@ki.se
Union representative
  • Andreas Lundqvist, SACO, 46 8 517 76884, andreas.lundqvist@ki.se;
  • Mimmi Shoshan, SACO, 46 8 517 75460
  • Helen Eriksson, OFR, 46 8 517 76279
Published 06.Sep.2017
Last application date 15.Sep.2017 11:59 PM CET